ABSTRACT
BACKGROUND: Diabetes Mellitus is characterized by hyperglycemia resulting either from deficiency in insulin secretion, insulin action or both. There is increasing evidence that excess production of highly reactive free radicals resulting in microvascular and macrovascular complications in diabetes. In Type 2 Diabetes Mellitus, antioxidants play a vital role to avoid this complications.In recent past, Dapagliflozin, a novel agent, an inhibitor of renal sodium glucose co- transporter 2 is being used to attain glycemic control. To know its pleotropic effect, especially as an antioxidant to prevent long term complications of diabetes mellitus, the antioxidant property of Dapagliflozin is evaluated by DPPH assay and scavenging of Nitric oxide Radicals. In this study it is compared against standard (ascorbic acid) and found to have significant Antioxidant property
ABSTRACT
Introduction: Reactive oxygen species like superoxide radicals, hydroxyl radicals, singlet oxygen are implicated in causing tissue injury and cytotoxicity. They play a vital role in various diseases like ischaemic disease, degenerative disease and many more. Prucalopride is a novel drug used in chronic constipation that acts as selective, high affinity 5-HT4 receptor agonist which targets the impaired motility. This in-vitro study was done with an objective to evaluate additional radical scavenging property of the drug prucalopride. Materials and Methods: In-vitro DPPH assay and Nitric oxide scavenging assay. Results: The methanol extract of the drug Prucalopride showed free radical scavenging effect with DPPH at the concentration of 1000 μg/ml. And also an increase in nitric oxide scavenging effect was observed with increased concentration of drug.
ABSTRACT
Background: Medical Council of India (MCI) insists on the training of Medical Teachers in Medical Education Technologies (MET). The need for such a training is debated by many teachers. Hence this study is taken up to analyse its benefits. Subjects & Methods: Seven batches of medical teachers from a private Medical College Hospital underwent a three day training in the basics of MET, as per the guidelines of MCI. Pretest and post test for evaluation and feedback on usefullness were obtained from the participants. Results & Discussion: The results analysed with the statistical Graphpad Prism6 software showed a significantly high post test marks 7.09/10±1.395 (mean±SD) compared to the pretest marks 2.184/10±1.019. (P value < 0.0001). Feedback in the Likertscale format from more than 95% of the participants also pronounced the usefulness of the programme. Conclusion: The statistically significant post test marks and the Feedback (Likertscale) from the participants vouch for the necessity of the training.